An iPSCs-based approach to model Type Two Diabetes in-vitro

An iPSCs-based approach to model Type Two Diabetes in-vitro

Internship Description

Studying the transcriptional and epigenetic mechanisms dysregulated in patients affected by metabolic disorders such as insulin resistance (IR) and type 2 diabetes mellitus (T2DM) is essential to derive efficient pharmacological approaches. We are seeking an outstanding student to work on a project focused on the study of the role of histone modifiers to the onset of metabolic disorders.​​

Deliverables/Expectations

The selected candidate will use human stem cells and terminally differentiated glucose sensitive cell types and will acquire skills in molecular biology techniques including Chromatin Immuno-precipitation (ChIP), quantitative real-time PCR (Q-PCR) and next generation sequencing (NGS).​

Faculty Name

Antonio Adamo

Field of Study

Molecular and Cellular Biology and/or Bioinformatics