Experimental validation of new neuro-vascular fractional model

Experimental validation of new neuro-vascular fractional model

Internship Description

The neurovascular coupling is a key mechanism linking the neural activity to the hemodynamic behavior.  Modeling of this coupling is very important to understand the brain function but it is at the same time very complex due to the complexity of the involved phenomena. Many studies have reported a time delay between the neural activity and the cerebral blood flow, which has been described by adding a delay parameter in some of the existing models. An alternative approach has been recently proposed where a fractional system is used to model the neurovascular coupling. Thanks to its nonlocal property, a fractional derivative is suitable for modeling phenomena with delay.  The model has been validated with extensive simulation study.

In this project, the student will validate the neuro-vascular fractional model using real cerebral blood flow and Blood Oxygen Level Dependent (BOLD) measurements. This work will be conducted with our collaborators from Ghent University. 

 

Deliverables/Expectations

Expect to submit a paper on this experimental validation​

Faculty Name

Taous Meriem Laleg

Field of Study

​​Electrical engineering/ Applied Mathematics