3D Bioprinting of Multicellular Constructs for the Development of Vascularized Skin Grafts

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Project Description

3D bioprinting technology has gained significant interest in biomedical engineering and regenerative medicine applications. However, current 3D bioprinting technologies utilize animal-based, plant-based, or synthetic polymer bioinks, which lowers biocompatibility with the patient. Additionally, the existing bioprinters use UV light or chemical treatment to polymerize the inks to form gels, which may cause unwanted mutations and faulty expressions of genes within the printed cells. The Laboratory for Nanomedicine at KAUST has developed a new technique which combines peptide-based bioinks and a robotic arm-based system for 3D bioprinting under true physiological conditions without any use of harsh physico-chemical methods. This project involves the development of vascularized skin grafts via 3D bioprinting of multicellular constructs for applications in the diabetic wound healing. Ultrashort peptide bioinks will be used as scaffolds for 3D bioprinting of human skin grafts.​​
Program - Computer Science
Division - Computer, Electrical and Mathematical Sciences and Engineering
Center Affiliation - Visual Computing Center
Field of Study - ​3D bioprinting, biomedical engineering, tissue engineering, regenerative medicine, vascularized skin grafts

About the
Researcher

Dominik L. Michels

Assistant Professor, Computer Science

Dominik L. Michels
The overarching goal of Professor Michels' research is enabling accurate and efficient simulations for scientific and visual computing. Towards this goal, he develops new principled computational methods based on solid theoretical foundations and contributes to a broad range of topics covering algorithmics, artificial intelligence and machine learning, computer graphics and physics-based modeling, differential equations, mathematical modeling, and numerical analysis.

Desired Project Deliverables

​Mastering 3D bioprinting using a commercial and a newly developed robotic 3D bioprinter (Hauser), Computational analysis of 3D bioprinting efficiency (Michels), creation of peptide bioinks (Hauser), developing skin grafts as a multicellular construct​