Distinguished Professor<br/>Director, KAUST Smart Health Initiative<br/>Biological & Environmental Sciences & Engineering Division<br/>
Professor Magistretti has made significant contributions in the field of brain energy metabolism. His group has discovered some of the cellular and molecular mechanisms that underlie the coupling between neuronal activity and energy consumption by the brain. This work has considerable ramifications for the understanding of the origin of the signals detected with the current functional brain imaging techniques used in neurologic and psychiatric research.
Magistretti’s research interests include the cellular and molecular bases of brain energy metabolism and brain imaging and the behavioral, cellular and molecular determinants of neuronal and glial plasticity.
Desired Project Deliverables
The student will learn to prepare, transfect and maintain HEK293 cells and primary cultures of neurons. She or he will also develop PLAs and use fluorescent microscopy to study the signaling role of lactate in the potentiation of NMDA receptors in neurons and in HEK293 cells expressing wild-type and/or mutant CaMKII/NMDA receptors