Molecular hospitality seen by NMR spectroscopy

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Project Description

Supramolecular chemistry is the domain of chemistry beyond that of molecules that focuses on the chemical systems made up of a discrete number of assembled molecular subunits or components stabilized usually by weak interactions as van der Waals or electrostatic forces, or hydrogen bonding. Cyclodextrins (CD), one group of so called host molecules, are macrocyclic oligosaccharides composed of several glucosidic units. Other molecules called guests can enter their cavity forming inclusion complexes. In aqueous solutions, CDs can form guest/host inclusion complexes with many partially or fully lipophilic molecules. The inclusion CD complexes are widely used in modification of solubility and stability of pharmaceuticals, food and cosmetic additives, or enzyme simulation studies. Many physicochemical methods have been used to study the formation of weak inclusion complexes in solid and liquid states. There is no doubt that some methods are better suited to study such complexes than others, and among the nonseparation methods nuclear magnetic resonance spectroscopy is one of the most widely used because it delivers a wealth of highly reliable information at the atomic resolution level.​
Program - BioScience
Division - Biological and Environmental Sciences and Engineering
Field of Study - ​chemistry, bioscience, physics, or engineering background

About the
Researcher

Mariusz Jaremko

Assistant Professor, Bioscience

Mariusz Jaremko

​The research group of Professor Mariusz Jaremko is focused on understanding and describing the basic principles of protein folding and misfolding, as well as the behavior of peptides and Intrinsically Disordered Proteins (IDPs) under different conditions, including conditions as close as possible to the physiological ones. To achieve these scientific goals, the state-of-the-art techniques of biomolecular NMR spectroscopy, together with other biophysical tools, are used. Understanding the biological phenomena which rule the protein folding and dynamics would allow for the design of new safe and biodegradable materials with desired physico-chemical properties, as well as the rational design of new drugs and efficient therapies against numerous neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and other protein aggregation-related diseases, like diabetes type II.​

Desired Project Deliverables

​Within the framework of the proposed project the participating student will learn about the supramolecular chemistry of cyclodextrin as well as extend own knowledge on the different host-guest interactions. The main method of the study of mentioned phenomena will be the Nuclear Magnetic Resonance (NMR) spectroscopy​