Protein Synthetic Biology

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Project Description

The student will work in the synthetic biology team of the Stefan Aroldlabin KAUST. The team is focusing on the design of multi-protein systems such as protein circuits or small metabolic pathways. We can offer both experimental (biophysical, molecular biology, automation) and computational or software development projects or a mix of the two.Experimental work would deal with the construction of small metabolic pathways or multi-protein circuits and their rapid prototyping in a cell-free expression system. We have started to combine this cell-free expression with microfluidics and are also actively developing automation workflows on the lab's liquid-handling robots. Software development projects would aim for improving biodesign and engineering workflows together with the experimentalists in the lab.​ ​
Program - BioScience
Division - Biological and Environmental Sciences and Engineering
Center Affiliation - Computational Bioscience Research Center
Field of Study - ​Synthetic Biology (experimental, computational)

About the
Researcher

Stefan T. Arold

Professor, Bioscience<br/>Associate Dean, Biological and Environmental Science and Engineering Division

Stefan T. Arold
​Professor Arold’s research interests are focused on integrative structural biology based on hybrid approaches. His work involves inferring structure and function of macromolecular assemblies, to enhance computational methods for functional annotation of genes (system-wide or focused), and to design and engineer molecules with desired properties (switches, genetic/epi-genetic regulators, detectors).

Desired Project Deliverables

​Exact deliverables depend on the type of work (experimental and / or computational). Experimental deliverables could be, for example, the expression and detection of a set of target proteins in microfluidic droplets or the automation of a cloning or protein expression experiment on a liquid handling robot. Software development would build on existing Python libraries to streamline biodesign workflows in the lab (e.g. multi-domain protein design).​