Cell-free Protein Synthesis of Next-Generation Therapeutics

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Project Description

Conventional expression systems require a time span of several days or even weeks for functional therapeutic protein prototyping. This lengthy duration hampers the speed of process development and extends the prototyping period. Moreover, these systems are limited to the 20 canonical amino acids, thereby limiting the production of next-generation therapeutics such as antibody-drug conjugates. Cell-free protein synthesis, also referred to as in vitro protein synthesis or CFPS, offers a potential solution to these constraints. The project’s objective is to explore and characterize our developed cell-free protein synthesis system. The system leverages the speed and adaptability of cell-free mechanisms to fast-track the prototyping of next-generation therapeutics. Project-duration will be 3-6 month, details of arrival/departure dates to be discussed.
Program - BioEngineering
Division - Biological and Environmental Sciences and Engineering
Center Affiliation - KAUST Catalysis Center
Field of Study - Cell-free Protein Synthesis; Bioengineering; Protein Chemistry; Biochemistry

About the
Researcher

Dominik Renn

Dominik Renn

Desired Project Deliverables

Students shall extend their general knowledge and skills in molecular biology and protein biochemistry. An emphasis will be put on expression, purification and characterization techniques. Students will be taught to work independently on projects, yet strengthening their critical sense to develop new ideas. In the course of the internship students shall demonstrate this understanding during oral presentations and one final written report.

RECOMMENDED STUDENT ACADEMIC & RESEARCH BACKGROUND

A background in biochemistry is preferred, but students with backgrounds in chemistry, biotechnology or biology
A background in biochemistry is preferred, but students with backgrounds in chemistry, biotechnology or biology are invited to apply
The ideal candidates should have some experience or interest in conducting standard biochemistry experiments
The ideal candidates should have some experience or interest in conducting standard biochemistry experiments
Experience with or interest in learning laboratory skills associated with analytical chemistry is beneficial
Experience with or interest in learning laboratory skills associated with analytical chemistry is beneficial