Dissecting the molecular basis of the neurodevelopmental features associated with Klinefelter syndrome

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Project Description

Klinefelter syndrome (KS) is the most common chromosome aneuploidy in humans. Our laboratory recently established a unique cohort of KS-iPSCs carrying 47,XXY, 48,XXXY, and 49,XXXXY karyotypes. We apply a disease-modeling approach to investigate the molecular basis of the neurodevelopmental features associated with KS during differentiation of KS-iPSCs into neurons using the most advanced brain-organoids differentiation methods. The Laboratory of Stem Cells and Diseases is seeking an outstanding internship student to work on the study of the role of critical X-linked transcription factors. The selected candidates will combine human iPSC cultures and genome-editing (CRISPR-Cas9) techniques.
Program - BioEngineering
Division - Biological and Environmental Sciences and Engineering
Faculty Lab Link - https://stemd.kaust.edu.sa
Field of Study - Disease-modeling, Brain-organoids, Stem Cells

About the
Researcher

Antonio Adamo

Assistant Professor, Bioscience

Antonio Adamo

Professor Adamo’s research interests focus on the study of the transcriptional and epigenetic mechanisms dysregulated in metabolic disorders such as Insulin Resistance (IR) and Type II Diabetes Mellitus (T2DM). His team relies on the use of the innovative reprogramming technique to derive induced pluripotent stem cells (iPSCs) from fibroblasts obtained from large cohorts of patients and healthy donors. iPSCs can be differentiated to virtually all cell types of the human body and therefore constitute an unprecedented cellular platform to model disease progression. Professor Adamo’s team combines reprogramming, next generation sequencing (NGS), genome editing and cellular biology techniques to identify the transcriptional and epigenetic signatures prognostic of metabolic diseases and to develop in vitro screening assays aimed to isolate chemical compounds able to revert these pathological signatures.

Desired Project Deliverables

The candidate will successfully differentiate disease and healthy iPSCs into disease-relevant tissues applying the most advanced 3D brain-organoids differentiation techniques.

RECOMMENDED STUDENT ACADEMIC & RESEARCH BACKGROUND

Cell Biology
Cell Biology
Molecular Biology
Molecular Biology