Klinefelter syndrome (KS) is the most common chromosome aneuploidy in humans. Our laboratory recently established a unique cohort of KS-iPSCs carrying 47,XXY, 48,XXXY, and 49,XXXXY karyotypes. We apply a disease-modeling approach to investigate the molecular basis of the neurodevelopmental features associated with KS during differentiation of KS-iPSCs into neurons using the most advanced brain-organoids differentiation methods. The Laboratory of Stem Cells and Diseases is seeking an outstanding internship student to work on the study of the role of critical X-linked transcription factors. The selected candidates will combine human iPSC cultures and genome-editing (CRISPR-Cas9) techniques.