Dissecting the molecular basis of the neurodevelopmental features associated with Klinefelter syndromeApply
Klinefelter syndrome (KS) is the most common chromosome aneuploidy in humans. Our laboratory recently established a unique cohort of KS-iPSCs carrying 47,XXY, 48,XXXY, and 49,XXXXY karyotypes. We apply a disease-modeling approach to investigate the molecular basis of the neurodevelopmental features associated with KS during differentiation of KS-iPSCs into neurons using the most advanced brain-organoids differentiation methods. The Laboratory of Stem Cells and Diseases is seeking an outstanding internship student to work on the study of the role of critical X-linked transcription factors. The selected candidates will combine human iPSC cultures and genome-editing (CRISPR-Cas9) techniques.
Program - BioEngineering
Division - Biological and Environmental Sciences and Engineering
Faculty Lab Link - https://stemd.kaust.edu.sa
Field of Study - Disease-modeling, Brain-organoids, Stem Cells
Assistant Professor, Bioscience
Desired Project Deliverables
The candidate will successfully differentiate disease and healthy iPSCs into disease-relevant tissues applying the most advanced 3D brain-organoids differentiation techniques.