Enzymatic Synthesis – Enzyme Characterization and Cascade Engineering

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Project Description

Biocatalysis has found numerous applications in various fields as a green and sustainable alternative to chemical catalysis. The potential of using enzymes in organic synthesis is high, especially to make chiral compounds for pharmaceuticals. The project focuses on the expression, purification and characterization of various enzyme classes for different synthesis targets. The enzymes will be tested alone or in combination in aqueous catalysis reactions and the influence of composition on selectivity and reactivity will be studied. Project-duration will be 3-6 month, details of arrival/departure dates to be discussed.
Program - BioScience
Division - All Divisions
Center Affiliation - KAUST Catalysis Center
Field of Study - Biochemistry

About the
Researcher

Magnus Rueping

Professor, Chemistry<br/>Associate Director, KAUST Catalysis Center

Magnus Rueping
Professor Rueping's research interests include organocatalysis, metal catalysis and biocatalysis; new reaction methodology and technology; smart materials, photochemistry and flow chemistry. 

Desired Project Deliverables

Students shall extend their general knowledge and skills in molecular biology and protein biochemistry. An emphasis will be put on expression, purification and characterization techniques. Students will be taught to work independently on projects, yet strengthening their critical sense to develop new ideas. In the course of the internship students shall demonstrate this understanding during oral presentations and one final written report.

RECOMMENDED STUDENT ACADEMIC & RESEARCH BACKGROUND

A background in biochemistry is preferred, but students with backgrounds in chemistry, biotechnology or biology are invited to apply.
A background in biochemistry is preferred, but students with backgrounds in chemistry, biotechnology or biology are invited to apply.
The ideal candidates should have some experience or interest in conducting standard enzymatic experiments.
The ideal candidates should have some experience or interest in conducting standard enzymatic experiments.
Experience with or interest in learning laboratory skills associated with analytical chemistry is beneficial.
Experience with or interest in learning laboratory skills associated with analytical chemistry is beneficial.