Anaerobic digestion (AD) is a well-established biotechnology for generating methane from high-strength organic wastes such as waste activated sludge (WAS). However, several bottlenecks exist that hinder their widespread application such as low start-up time, low methane content and yield, and high susceptibility to environmental perturbation. One strategy to alleviate these bottlenecks is to integrate AD with microbial electrolysis cell (MEC). In MEC, acetoclastic electroactive bacteria (EAB) are considered the key functional groups responsible for recovering energy from acetate. In this project, we will study the effect of different start-up strategies with functionally redundant and efficient acetoclastic EAB on the performance of integrated MEC-AD fed with WAS.