Investigating the Design and Engineering of Nanobodies for Advanced Biomedical Applications

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Project Description

This project focuses on the engineering and design of nanobodies, the smallest functional antibody fragments derived from camelid heavy-chain-only antibodies. Due to their small size, stability, and solubility, nanobodies are ideal for economical antigen capture in diagnostics, therapeutics, and biosensing. Moreover, the project also explores latest advancements in nanobody generation methods, and epitope prediction aided by computational techniques. Project-duration will be 3-6 month, details of arrival/departure dates to be discussed.
Program - BioEngineering
Division - Biological and Environmental Sciences and Engineering
Center Affiliation - KAUST Catalysis Center
Field of Study - Nanobody; Bioengineering; Protein Chemistry; Biochemistry

About the
Researcher

Dominik Renn

Dominik Renn

Desired Project Deliverables

Students shall extend their general knowledge and skills in molecular biology and protein biochemistry. An emphasis will be put on expression, purification and characterization techniques. Students will be taught to work independently on projects, yet strengthening their critical sense to develop new ideas. In the course of the internship students shall demonstrate this understanding during oral presentations and one final written report.

RECOMMENDED STUDENT ACADEMIC & RESEARCH BACKGROUND

A background in biochemistry is preferred, but students with backgrounds in chemistry, biotechnology or biology
A background in biochemistry is preferred, but students with backgrounds in chemistry, biotechnology or biology are invited to apply
The ideal candidates should have some experience or interest in conducting standard biochemistry experiments
The ideal candidates should have some experience or interest in conducting standard biochemistry experiments
Experience with or interest in learning laboratory skills associated with mass spectrometry is beneficial
Experience with or interest in learning laboratory skills associated with mass spectrometry is beneficial