Predicting Bacterial Antimicrobial Resistance Phenotypes from Genomic Biomarkers
ApplyProject Description
The Infectious Disease Epidemiology lab of Prof. Danesh Moradigaravand
is looking for student interns to work on a range of projects on the
intersection of machine learning and microbial genomics. We are interested
in understanding the evolution and epidemiology of antimicrobial resistance
strains recovered from natural sources, including clinical and environmental
sites. Antimicrobial resistance is a global health threat, expected to become
a leading cause of deaths worldwide within the next three decades. This is
predominately due to the rapid emergence of novel genetic variants, which
lead to new resistance mechanisms. The understanding of the genetic
repertoire of resistance is henceforth important to design new antimicrobial
strategies and develop new compounds. In this project, the student will
develop a machine learning-based predictive model to systematically
identify resistance determinants in bacterial genomes. The projects
involves integration of genomic and phenomic data, generated by high
throughput phenotypic assays using an off-the-shelf machine learning
method. The student will implement an entire predictive pipeline and deploy
the model as a data science solution. The project helps student gain
hands-on experience of programming, next generation sequencing data
analysis and machine learning
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About the
Researcher
Danesh Moradigaravand
![Danesh Moradigaravand](/SFRes/images/Telerik.Sitefinity.Resources/Images.DefaultPhoto.png)
Desired Project Deliverables
Develop and deploy a machine learning pipeline
Disclose a database of predictive biomarkers for antimicrobial resistance
Contribute to relevant publications