Unraveling the molecular basis of immune signaling
ApplyProject Description
All animals and plants form ‘holobionts’ with a myriad of microorganisms. Accordingly, all organisms have evolved sophisticated immune mechanisms to fight pathogenic microbes, while attracting and nurturing beneficial ones. We use biochemistry, biophysics and structural methods such as X-ray crystallography, small angle X-ray scattering, nuclear magnetic resonance, cryo-electron microscopy and AI-based predictions to reveal the 3D structure of protein complexes involved in controlling the immune system. The student will be embedded in a team of structural biologists and will work on protein production, biophysical and 3D structural analyses. In KAUST we have access to state-of-the art instruments, including last-generation TITAN KRIOS electron microscopes, and high-field NMR; X-ray analysis is performed in France. Prior wet-lab experience would be a plus.



About the
Researcher
Stefan T. Arold
Professor, Bioscience<br/>Associate Dean, Biological and Environmental Science and Engineering Division

Professor Arold’s research interests are focused on integrative structural biology based on hybrid approaches. His work involves inferring structure and function of macromolecular assemblies, to enhance computational methods for functional annotation of genes (system-wide or focused), and to design and engineer molecules with desired properties (switches, genetic/epi-genetic regulators, detectors).
Desired Project Deliverables
The student will be embedded in a team of structural biologists and will work on protein production, biophysical and 3D structural analyses.